Pharmacological Effects of .SIGMA.-Receptor Ligands. Development of .SIGMA.-receptor ligands and clinical trials.
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چکیده
منابع مشابه
Sigma-2 receptor ligands QSAR model dataset
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2 (σ2) receptor ligands selective over Sigma-1 (σ1) receptor. The development of the QSAR model has been undertaken with the use of CORAL software using SMILES, molecular graphs and hybrid descriptors (...
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It has been shown previously that sigma receptor agonists reveal potential antidepressant activity in experimental models. Moreover, some data indicate sigma receptor contribution to stress-induced responses (e.g., conditioned fear stress in mice), though the mechanism by which sigma ligands can exert their effects, remains unclear. Recent studies have indicated that antidepressant drugs (ADs) ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1999
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.114.3